Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.75 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.75 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.75 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.75 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.75 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.75 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.75 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.75 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.75 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.75 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.75 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.75 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.75 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.75 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.75 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.75 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.75 |
| ▸ | MTOR | P42345 | 3/20 | 0.75 |
| ▸ | PRKDC | P78527 | 1/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622896 | 1.00 | HDAC1 (0.75) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1622435 | 1.00 | HDAC1 (0.75) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1284539 | 0.91 | HDAC1 (0.61) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1622588 | 0.89 | HDAC1 (0.74) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1622877 | 0.89 | HDAC1 (0.74) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1284110 | 0.89 | HDAC1 (0.74) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1284408 | 0.89 | PIK3CA (0.61) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1622359 | 0.88 | HDAC1 (0.58) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1620724 | 0.88 | HDAC1 (0.58) | HDAC1PIK3CAHDAC2HDAC10HDAC11 | |
| SCHEMBL1620729 | 0.88 | HDAC1 (0.58) | HDAC1PIK3CAHDAC2HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250230169-A1 | Phosphoinositide 3-Kinase Inhibitors with a Zinc Binding Moiety | CURIS INC (US) | 2025-07-17 | — | — | US | disclosed |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2023-07-20 | — | — | US | disclosed |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2023-07-20 | — | — | US | disclosed |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2023-07-20 | — | — | US | disclosed |
| US-11597732-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | CURIS, INC. (US) | 2023-03-07 | — | — | US | disclosed |
| US-20220402934-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2022-12-22 | — | — | US | disclosed |
| US-20220402934-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2022-12-22 | — | — | US | disclosed |
| US-11261195-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | CURIS, INC. (US) | 2022-03-01 | — | — | US | disclosed |
| US-20210214370-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2021-07-15 | — | — | US | disclosed |
| US-20210214370-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS INC (US) | 2021-07-15 | — | — | US | disclosed |
| US-8461157-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | CURIS, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. | 2013-04-25 | — | — | US | disclosed |
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. | 2013-04-25 | — | — | US | disclosed |
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. | 2013-04-25 | — | — | US | disclosed |
| EP-2557923-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | Curis, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2012-04-12 | — | — | US | disclosed |
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2012-04-12 | — | — | US | disclosed |
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | CURIS, INC. | 2012-04-12 | — | — | US | disclosed |
| WO-2011130628-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011130628-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | CURIS, INC. (US) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11261195-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3CA 57/4885HDAC2 27/4885 |
| US-20210214370-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3CA 58/4885HDAC2 27/4885 |
| US-11597732-B2 | Phosphoinositide 3-kinase inhibitors with a zinc binding moiety | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3CA 58/4885HDAC2 27/4885 |
| US-20250230169-A1 | Phosphoinositide 3-Kinase Inhibitors with a Zinc Binding Moiety | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3CA 57/4885HDAC2 27/4885 |
| US-20120088764-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3CA 57/4885HDAC2 27/4885 |
| US-20230227467-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3CA 57/4885HDAC2 27/4885 |
| US-20220402934-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH A ZINC BINDING MOIETY | BAZ2A, BAZ2B, PI4KB | HDAC1 10/4885PIK3CA 57/4885HDAC2 27/4885 |
| US-20130102595-A1 | TREATMENT OF CANCERS HAVING K-RAS MUTATIONS | KRAS, HRAS, KSR2 | HDAC1 6/4885PIK3CA 31/4885HDAC2 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.