Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.40 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | XIAP | P98170 | 3/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12847767 | 1.00 | NOTUM (0.42) | NOTUMAKT1HTR2CHTR2AHDAC1 | |
| SCHEMBL12847355 | 0.92 | AKT1 (0.47) | NOTUMAKT1HTR2CHTR2AHDAC1 | |
| SCHEMBL17771699 | 0.83 | NOTUM (0.46) | NOTUMAKT1HTR2CHTR2AHTR2B | |
| SCHEMBL17771690 | 0.83 | NOTUM (0.46) | NOTUMAKT1HTR2CHTR2AHTR2B | |
| SCHEMBL4262376 | 0.81 | HDAC1 (0.38) | NOTUMAKT1HTR2CHTR2AHDAC1 | |
| SCHEMBL3666216 | 0.79 | NOTUM (0.42) | NOTUMAKT1HTR2CHTR2AHTR2B | |
| SCHEMBL12790852 | 0.79 | NOTUM (0.42) | NOTUMAKT1HTR2CHTR2AHTR2B | |
| SCHEMBL12847641 | 0.78 | NOTUM (0.47) | NOTUMHTR2CHTR2AHDAC1HDAC6 | |
| SCHEMBL12847311 | 0.77 | NOTUM (0.43) | NOTUMHDAC1HDAC6SLC6A3KCNK2 | |
| SCHEMBL12847765 | 0.77 | GRIA2 (0.37) | AKT1HTR2CHDAC1HDAC6HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072500-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-8324221-B2 | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2012-12-04 | — | — | US | disclosed |
| US-20110053959-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053959-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, PIK3CA | NOTUM 2711/4885AKT1 1/4885HTR2C 2734/4885 |
| US-20130072500-A1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | PIK3CA, AKT1, AKT2 | NOTUM 2603/4885AKT1 2/4885HTR2C 2325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.