Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12796746 | 0.94 | TYRO3 (0.32) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL10145275 | 0.89 | TYRO3 (0.38) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL541487 | 0.87 | LRRK2 (0.39) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL12796719 | 0.86 | GSK3A (0.39) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL541701 | 0.85 | KMT2A (0.40) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL541700 | 0.85 | HDAC3 (0.37) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL12796743 | 0.85 | TYRO3 (0.36) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL15397221 | 0.83 | GSK3A (0.37) | HDAC3HDAC1HDAC2HDAC6GABBR2 | |
| SCHEMBL15397167 | 0.83 | LRRK2 (0.36) | ALDH1A1LMNATYRO3CNR1CNR2 | |
| SCHEMBL12796750 | 0.81 | KMT2A (0.36) | HDAC3HDAC1HDAC2HDAC6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053912-A1 | PYRIMIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053912-A1 | PYRIMIDINE COMPOUND | CNR2, CNR1, P2RY2 | HDAC3 2151/4885HDAC1 3139/4885HDAC2 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.