Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 15/20 | 0.52 |
| ▸ | CCNK | O75909 | 6/20 | 0.45 |
| ▸ | CDK9 | P50750 | 6/20 | 0.45 |
| ▸ | CDK14 | O94921 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CCNH | P51946 | 1/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12850332 | 0.91 | CCNT1 (0.48) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL15378039 | 0.88 | CCNT1 (0.55) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL15378038 | 0.88 | CCNT1 (0.55) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL8784970 | 0.86 | CCNT1 (0.48) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL12850674 | 0.86 | CCNT1 (0.46) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL12850672 | 0.86 | CCNT1 (0.46) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL12850336 | 0.84 | CCNT1 (0.49) | CCNT1 | |
| SCHEMBL12850334 | 0.83 | CCNT1 (0.60) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL12850537 | 0.83 | CCNT1 (0.60) | CCNT1CCNKCDK9CDK14CDK1 | |
| SCHEMBL12850328 | 0.83 | CCNT1 (0.47) | CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101062-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |