Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224789 | 0.91 | BTK (0.82) | BTKCLK2 | |
| SCHEMBL1725222 | 0.91 | BTK (1.00) | BTKCLK2 | |
| SCHEMBL1727170 | 0.90 | BTK (0.81) | BTKCLK2 | |
| SCHEMBL1726617 | 0.90 | BTK (0.81) | BTKCLK2 | |
| SCHEMBL1725376 | 0.85 | BTK (0.86) | BTKCLK2 | |
| SCHEMBL13178747 | 0.84 | BTK (0.80) | BTKCLK2 | |
| SCHEMBL1726871 | 0.84 | BTK (0.81) | BTK | |
| SCHEMBL3215076 | 0.84 | BTK (0.71) | BTKCLK2 | |
| SCHEMBL1725205 | 0.83 | BTK (0.73) | BTKCLK2 | |
| SCHEMBL1727079 | 0.83 | BTK (1.00) | BTKCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906509-B2 | Inhibitors of bruton's tyrosine kinase | ROCHE PALO ALTO LLC (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100099659-A1 | Inhibitors of Bruton's Tyrosine Kinase | KENNEDY-SMITH JOSHUA | 2010-04-22 | — | — | US | disclosed |
| US-20090306041-A1 | Inhibitors of Bruton's tyrosine kinase | ROCHE PALO ALTO LLC | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099659-A1 | Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LYN | BTK 1/4885CLK2 575/4885 |
| US-20090306041-A1 | Inhibitors of Bruton's tyrosine kinase | BTK, SYK, LYN | BTK 1/4885CLK2 575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.