Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 11/20 | 0.42 |
| ▸ | CA1 | P00915 | 11/20 | 0.42 |
| ▸ | CA2 | P00918 | 11/20 | 0.42 |
| ▸ | CA9 | Q16790 | 11/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gw416981X SCHEMBL14040791 | 0.88 | CDK1 (0.45) | CDK1CDK2CA12CA1CA2 | |
| Gw416981X SCHEMBL5425650 | 0.88 | CDK1 (0.45) | CDK1CDK2CA12CA1CA2 | |
| Gw416981X SCHEMBL5425654 | 0.88 | CDK1 (0.45) | CDK1CDK2CA12CA1CA2 | |
| SCHEMBL7654637 | 0.85 | TLK2 (0.47) | CA12CA1CA2CA9PDPK1 | |
| SCHEMBL12856336 | 0.85 | TLK2 (0.47) | CA12CA1CA2CA9PDPK1 | |
| SCHEMBL5182747 | 0.84 | AURKA (0.53) | CA12CA1CA2CA9PDPK1 | |
| SCHEMBL12856526 | 0.84 | AURKA (0.53) | CA12CA1CA2CA9PDPK1 | |
| SCHEMBL5182752 | 0.84 | AURKA (0.53) | CA12CA1CA2CA9PDPK1 | |
| SCHEMBL12856391 | 0.83 | AURKA (0.39) | CDK1CDK2CA12CA1CA2 | |
| SCHEMBL5894173 | 0.83 | KMT2A (0.52) | CA12CA1CA2CA9KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1364212-B1 | THREE HYBRID ASSAY SYSTEM | GPC BIOTECH AG (DE) | 2011-02-02 | — | — | EP | disclosed |