Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122160 | 0.84 | BRAF (1.00) | BRAF | |
| SCHEMBL1122264 | 0.78 | BRAF (1.00) | BRAF | |
| SCHEMBL1122497 | 0.76 | BRAF (1.00) | BRAF | |
| SCHEMBL182882 | 0.74 | SMN1; SMN2 (0.58) | — | |
| SCHEMBL16739611 | 0.69 | BRAF (0.53) | BRAF | |
| SCHEMBL1122168 | 0.68 | BRAF (1.00) | BRAF | |
| SCHEMBL1122307 | 0.68 | BRAF (1.00) | BRAF | |
| SCHEMBL4848378 | 0.68 | TRPV1 (0.67) | BRAF | |
| SCHEMBL4996034 | 0.67 | KDR (0.74) | BRAF | |
| SCHEMBL4993806 | 0.66 | BRAF (0.72) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831184-B1 | PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS | WELLCOME TRUST LTD (GB) | 2011-02-09 | — | — | EP | disclosed |