Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA4 | P43681 | 19/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 13/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 12/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 12/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 11/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12658107 | 0.84 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL12658328 | 0.78 | CHRNA4 (0.52) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL14207023 | 0.74 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL14207613 | 0.71 | CHRNA4 (0.53) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL12859131 | 0.70 | CHRNA4 (0.50) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL12858897 | 0.69 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL12858747 | 0.69 | CHRNA4 (0.50) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL14207363 | 0.69 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL14207463 | 0.69 | CHRNA4 (0.49) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL12658201 | 0.69 | CHRNA4 (0.50) | CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284171-A1 | Amides of diazabicycloalkanes selective for nicotinic acetylcholine receptor sub-types | Targacept, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2008057938-A1 | NICOTINIC ACETYLCHOLINE RECEPTORSUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES | TARGACEPT, INC. (US) | 2008-05-15 | — | — | WO | disclosed |