Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 7/20 | 0.77 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.66 |
| ▸ | INSR | P06213 | 5/20 | 0.66 |
| ▸ | IGF1R | P08069 | 5/20 | 0.66 |
| ▸ | EGFR | P00533 | 5/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | STK25 | O00506 | 1/20 | 0.57 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.57 |
| ▸ | CASK | O14936 | 1/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | GAK | O14976 | 1/20 | 0.57 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.57 |
| ▸ | MUSK | O15146 | 1/20 | 0.57 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12781151 | 0.93 | ZAP70 (0.75) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12780497 | 0.92 | ZAP70 (0.74) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12781668 | 0.92 | ZAP70 (0.91) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12780077 | 0.92 | ZAP70 (0.74) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12780203 | 0.91 | ZAP70 (0.72) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12780492 | 0.90 | ZAP70 (0.71) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12781068 | 0.90 | ZAP70 (0.71) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL10209508 | 0.87 | ZAP70 (0.69) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12780131 | 0.87 | ZAP70 (1.00) | ZAP70ALKINSRIGF1REGFR | |
| SCHEMBL12728756 | 0.87 | ZAP70 (0.66) | ZAP70ALKINSRIGF1REGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287156-A1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | Novartis AG (CH) | 2011-02-23 | — | — | EP | disclosed |