SCHEMBL1286658

SCHEMBL1286658

Cc1noc(-c2ccc(-c3ccc(CC(=O)O)cc3)cc2)c1NC(=O)OCCc1ccccc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPAR1 Q92633 6/20 0.68
LPAR3 Q9UBY5 4/20 0.62
LPAR2 Q9HBW0 2/20 0.62
ABCC4 O15439 2/20 0.46
ABCC3 O15438 1/20 0.46
ABCB11 O95342 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2C9 P11712 1/20 0.46
ABCB4 P21439 1/20 0.46
ABCC2 Q92887 1/20 0.46
SLCO1B3 Q9NPD5 1/20 0.46
SLCO1B1 Q9Y6L6 1/20 0.46
ROCK2 O75116 1/20 0.45
MGLL Q99685 1/20 0.45
KDM4E B2RXH2 2/20 0.43
ENPP2 Q13822 1/20 0.43
MAPT P10636 1/20 0.43
TSHR P16473 2/20 0.40
LMNA P02545 1/20 0.40
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3714449 0.92 LPAR1 (0.58) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2225512 0.92 LPAR1 (0.58) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2341771 0.91 LPAR1 (0.60) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2335063 0.91 LPAR1 (0.57) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2337677 0.90 LPAR1 (0.64) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2338531 0.90 LPAR1 (0.61) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2338268 0.89 LPAR1 (0.68) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2341435 0.89 LPAR1 (0.53) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL2335542 0.89 LPAR1 (0.61) LPAR1LPAR3LPAR2ABCC4ABCC3
SCHEMBL3709529 0.88 LPAR1 (0.54) LPAR1LPAR3LPAR2ABCC4ABCC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011159632-A1 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS OR DISEASES OF THE EYE AMIRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO claimed
WO-2011159550-A2 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONIST AND USES THEREOF AMIDRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO claimed
WO-2011159635-A1 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONIST FOR THE TREATMENT OF DERMAL CONDITIONS AMIRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO claimed
WO-2011159633-A1 INHALABLE FORMULATIONS OF LYSOPHOSPHATDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO claimed
EP-2858635-A1 INHIBITORS OF HIPPO-YAP SIGNALING PATHWAY The Regents of The University of California (US) 2015-04-15 EP disclosed
WO-2013188138-A1 INHIBITORS OF HIPPO-YAP SIGNALING PATHWAY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-12-19 WO disclosed
WO-2011159550-A3 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONIST AND USES THEREOF AMIRA PHARMACEUTICALS, INC. (US) 2012-04-05 WO disclosed
WO-2011159550-A2 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONIST AND USES THEREOF AMIDRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO disclosed
WO-2011159632-A1 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CONDITIONS OR DISEASES OF THE EYE AMIRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO disclosed
WO-2011159550-A2 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONIST AND USES THEREOF AMIDRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO disclosed
WO-2011159635-A1 LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONIST FOR THE TREATMENT OF DERMAL CONDITIONS AMIRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO disclosed
WO-2011159633-A1 INHALABLE FORMULATIONS OF LYSOPHOSPHATDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-12-22 WO disclosed
EP-2358688-A2 ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS Amira Pharmaceuticals, Inc. (US) 2011-08-24 EP disclosed
WO-2010077883-A2 ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS AMIRA PHARMACEUTICALS, INC. (US) 2010-07-08 WO disclosed
WO-2010077882-A2 ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS AMIRA PHARMACEUTICALS, INC. (US) 2010-07-08 WO disclosed