Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 12/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | HTT | P42858 | 5/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.72 |
| ▸ | CRHBP | P24387 | 2/20 | 0.72 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12869971 | 0.92 | MEN1 (0.73) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL13888269 | 0.91 | MEN1 (1.00) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL38659614 | 0.86 | TDP1 (0.75) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL38660303 | 0.86 | TDP1 (0.75) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL38660692 | 0.85 | MEN1 (0.76) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL12869892 | 0.85 | MEN1 (0.86) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL12869852 | 0.85 | KDM4E (0.70) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL13310285 | 0.85 | TDP1 (0.70) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL10674767 | 0.84 | MEN1 (1.00) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL12870001 | 0.83 | TDP1 (1.00) | MEN1KMT2AKDM4EHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110034472-A1 | Novel Compounds for Treatment of Cancer and Disorders Associated With Angiogenesis Function | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-02-10 | — | — | US | disclosed |
| US-20100120781-A1 | Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function | UNIVERSITY OF SOUTHERN CALIFORNIA | 2010-05-13 | — | — | US | disclosed |
| US-20100120781-A1 | Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function | UNIVERSITY OF SOUTHERN CALIFORNIA | 2010-05-13 | — | — | US | disclosed |
| US-20090093489-A1 | NOVEL COMPOUNDS FOR TREATMENT OF CANCER AND DISORDERS ASSOCIATED WITH ANGIOGENESIS FUNCTION | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-09 | — | — | US | disclosed |
| US-20090093489-A1 | NOVEL COMPOUNDS FOR TREATMENT OF CANCER AND DISORDERS ASSOCIATED WITH ANGIOGENESIS FUNCTION | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034472-A1 | Novel Compounds for Treatment of Cancer and Disorders Associated With Angiogenesis Function | VEGFA, TEK, MCL1 | MEN1 2560/4885KMT2A 3993/4885KDM4E 3554/4885 |
| US-20090093489-A1 | NOVEL COMPOUNDS FOR TREATMENT OF CANCER AND DISORDERS ASSOCIATED WITH ANGIOGENESIS FUNCTION | VEGFA, TEK, MCL1 | MEN1 2560/4885KMT2A 3993/4885KDM4E 3554/4885 |
| US-20100120781-A1 | Novel Compounds for Treatment of Cancer and Disorders Associated with Angiogenesis Function | VEGFA, TEK, MCL1 | MEN1 2560/4885KMT2A 3993/4885KDM4E 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.