Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citalopram. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 14/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.98 |
| ▸ | HTR2C | P28335 | 2/20 | 0.98 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.98 |
| ▸ | HRH1 | P35367 | 2/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.98 |
| ▸ | DRD3 | P35462 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | NPC1 | O15118 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | HTR1A | P08908 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | DRD1 | P21728 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citalopram SCHEMBL1693551 | 1.00 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| Citalopram SCHEMBL1118 | 1.00 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| Escitalopram SCHEMBL522164 | 1.00 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| Citalopram SCHEMBL41352 | 1.00 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| Citalopram SCHEMBL946 | 0.99 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| (R)-Citalopram SCHEMBL29414626 | 0.99 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| Citalopram SCHEMBL29494157 | 0.99 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| Escitalopram SCHEMBL34948 | 0.99 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| Citalopram SCHEMBL3858802 | 0.99 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 | |
| (R)-Citalopram SCHEMBL13235283 | 0.99 | SLC6A4 (1.00) | SLC6A4MAPK1BLMPMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906208-A1 | THERAPEUTIC TREATMENT | Sears, Douglas (US) | 2015-08-19 | — | — | EP | disclosed |
| WO-2012048243-A2 | DEPRESSION DISORDER THERAPEUTICS WITH CREATINE ANALOGS | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-04-12 | — | — | WO | disclosed |
| EP-2254564-A1 | COMBINATIONS COMPRISING 3-PHENYLSULFONYL-8-PIPERAZINYL-1YL-QUINOLINE | Glaxo Group Limited (GB) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009074607-A1 | COMBINATIONS COMPRISING 3-PHENYLSULFONYL-8-PIPERAZINYL-1YL-QUINOLINE | GLAXO GROUP LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |
| WO-2005070914-A1 | A METHOD FOR THE PREPARATION OF CITALOPRAM ACID ADDITION SALTS | JUBILANT ORGANOSYS LIMITED (IN) | 2005-08-04 | — | — | WO | disclosed |