Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 11/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287047 | 1.00 | PLG (0.44) | PLGGAAGABRA1GABRG2GABRB3 | |
| SCHEMBL1287049 | 1.00 | PLG (0.44) | PLGGAAGABRA1GABRG2GABRB3 | |
| SCHEMBL1287012 | 0.88 | PLG (0.44) | PLGGABRA1GABRG2GABRB3THRB | |
| SCHEMBL1287051 | 0.85 | PLG (0.44) | PLGGABRA1GABRG2GABRB3THRB | |
| SCHEMBL1287048 | 0.85 | PLG (0.44) | PLGGABRA1GABRG2GABRB3THRB | |
| SCHEMBL1287094 | 0.85 | PLG (0.44) | PLGGABRA1GABRG2GABRB3THRB | |
| SCHEMBL1287052 | 0.84 | PLG (0.40) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL1287098 | 0.84 | PLG (0.40) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL1287036 | 0.84 | PLG (0.40) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL581377 | 0.82 | PLG (0.52) | PLGGABRA1GABRG2GABRB3THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047156-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS PLASMINOGEN INHIBITORS AND THEIR USE IN THE TREATMENT OF FIBRINOLYSIS RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |