Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 20/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1183820 | 0.95 | CETP (0.79) | CETPKCNH2 | |
| SCHEMBL12871529 | 0.90 | CETP (0.89) | CETPKCNH2 | |
| SCHEMBL12871530 | 0.90 | CETP (0.89) | CETPKCNH2 | |
| SCHEMBL12871524 | 0.88 | CETP (0.74) | CETPKCNH2 | |
| SCHEMBL1182918 | 0.85 | CETP (0.87) | CETPKCNH2 | |
| SCHEMBL1182920 | 0.85 | CETP (0.87) | CETPKCNH2 | |
| SCHEMBL1182381 | 0.84 | CETP (0.82) | CETPKCNH2 | |
| SCHEMBL1182382 | 0.84 | CETP (0.82) | CETPKCNH2 | |
| SCHEMBL1183096 | 0.84 | CETP (1.00) | CETPKCNH2 | |
| SCHEMBL1182520 | 0.84 | CETP (1.00) | CETPKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888376-B2 | Cholesteryl ester transfer protein (CETP) inhibitors; atherosclerosis and cardiovascular diseases; N-(1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-phenylethyl)-4-(trifluoromethyl)thiazol-2-amine; Alzheimer's, atherosclerosis, venous thrombosis, peripheral vascular disease | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-15 | — | — | US | disclosed |