Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 13/20 | 0.38 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | IDH1 | O75874 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 7/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11029321 | 0.89 | IDH1 (0.43) | BRAFRAF1IDH1EGFRDDR2 | |
| SCHEMBL11027734 | 0.89 | IDH1 (0.39) | BRAFRAF1IDH1EGFRDDR2 | |
| SCHEMBL11031849 | 0.88 | IDH1 (0.40) | BRAFRAF1IDH1EGFRDDR2 | |
| SCHEMBL1160958 | 0.88 | IDH1 (0.47) | AURKABRAFRAF1IDH1EGFR | |
| SCHEMBL1161162 | 0.87 | BRAF (0.38) | BRAFRAF1EGFR | |
| SCHEMBL1161307 | 0.87 | PARP10 (0.39) | BRAFRAF1EGFRDDR2 | |
| SCHEMBL1160829 | 0.86 | RAF1 (0.38) | BRAFRAF1IDH1 | |
| SCHEMBL1160828 | 0.85 | DDR2 (0.40) | BRAFRAF1IDH1EGFRDDR2 | |
| SCHEMBL1161279 | 0.85 | BRAF (0.39) | BRAFRAF1EGFR | |
| SCHEMBL15195877 | 0.84 | DDR2 (0.38) | BRAFRAF1IDH1EGFRDDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011017142-A1 | NOVEL BICYCLIC UREA COMPOUNDS | MERCK PATENT GMBH (DE) | 2011-02-10 | — | — | WO | disclosed |