Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 17/20 | 0.57 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1157670 | 0.89 | ZAP70 (0.63) | ZAP70JAK2JAK1 | |
| SCHEMBL12795259 | 0.86 | ZAP70 (0.76) | ZAP70JAK2JAK1FER | |
| SCHEMBL1158452 | 0.86 | ZAP70 (0.76) | ZAP70JAK2JAK1FER | |
| SCHEMBL1158240 | 0.85 | ZAP70 (0.62) | ZAP70JAK2JAK1FER | |
| SCHEMBL12849057 | 0.78 | ZAP70 (0.67) | ZAP70JAK2JAK1FER | |
| SCHEMBL1048890 | 0.78 | ZAP70 (0.66) | ZAP70JAK2JAK1 | |
| SCHEMBL12794833 | 0.78 | ZAP70 (0.68) | ZAP70FER | |
| SCHEMBL1048263 | 0.77 | ZAP70 (0.56) | ZAP70JAK2JAK1FER | |
| SCHEMBL1049968 | 0.76 | ZAP70 (0.72) | ZAP70 | |
| SCHEMBL12873992 | 0.76 | ZAP70 (0.73) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011014515-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-02-03 | — | — | WO | disclosed |