Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.34 |
| ▸ | PIK3R3 | Q92569 | 2/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1198506 | 0.93 | PDE7A (0.41) | CCNA2CDK2CCNA1PDE7APDE3A | |
| SCHEMBL12046652 | 0.91 | PDE7A (0.41) | CCNA2CDK2CCNA1PDE7APDE3A | |
| SCHEMBL1198377 | 0.91 | CCNA2 (0.41) | CCNA2CDK2CCNA1PDE7APDE3A | |
| SCHEMBL1199362 | 0.91 | PDE7A (0.42) | CCNA2CDK2CCNA1PDE7APDE3A | |
| SCHEMBL1199255 | 0.90 | PDE7A (0.40) | CCNA2CDK2CCNA1PDE7APDE3A | |
| SCHEMBL1199721 | 0.89 | PDE7A (0.39) | PDE7APDE3APDE10APIK3CDPIK3R2 | |
| SCHEMBL1199426 | 0.88 | PDE7A (0.39) | PDE7APDE3APDE10ACA2MAPT | |
| SCHEMBL12046672 | 0.88 | CCNA2 (0.43) | CCNA2CDK2CCNA1PDE7APDE3A | |
| SCHEMBL1199686 | 0.88 | PDE10A (0.42) | CCNA2CDK2CCNA1PDE7APDE3A | |
| SCHEMBL1199219 | 0.88 | PDE7A (0.42) | CCNA2CDK2CCNA1PDE7APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |
| WO-2011012674-A1 | DIHYDROBENZOINDAZOLES | N.V. ORGANON (NL) | 2011-02-03 | — | — | WO | disclosed |