Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.51 |
| ▸ | JAK3 | P52333 | 19/20 | 0.51 |
| ▸ | JAK2 | O60674 | 18/20 | 0.51 |
| ▸ | TYK2 | P29597 | 18/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920226 | 0.90 | JAK1 (0.48) | JAK1JAK3JAK2TYK2NPC1 | |
| SCHEMBL12875466 | 0.88 | JAK3 (0.50) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL9920282 | 0.86 | JAK2 (0.58) | JAK1JAK3JAK2TYK2NPC1 | |
| SCHEMBL9920212 | 0.80 | JAK3 (0.47) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL1160541 | 0.74 | JAK1 (0.60) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL9920216 | 0.73 | JAK3 (0.47) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL9920227 | 0.72 | JAK2 (0.48) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL9923339 | 0.71 | JAK2 (0.58) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL12875103 | 0.71 | JAK2 (0.57) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL9920225 | 0.71 | JAK2 (0.53) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011014817-A1 | PYRROLO [1, 2-B] PYRIDAZINE DERIVATIVES AS JANUS KINASE INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-02-03 | — | — | WO | disclosed |