Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.57 |
| ▸ | JAK3 | P52333 | 17/20 | 0.57 |
| ▸ | JAK2 | O60674 | 14/20 | 0.57 |
| ▸ | TYK2 | P29597 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1154170 | 0.91 | JAK1 (0.65) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL4440771 | 0.80 | JAK1 (0.68) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL4440769 | 0.80 | JAK1 (0.68) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL4440765 | 0.80 | JAK1 (0.68) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL12888138 | 0.75 | JAK1 (0.64) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL12876848 | 0.75 | JAK1 (0.68) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL12888915 | 0.74 | JAK3 (0.62) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL1154788 | 0.74 | JAK1 (0.71) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL1154946 | 0.74 | JAK1 (0.71) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL1154172 | 0.74 | JAK1 (0.67) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039822-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039822-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | JAK3, JAK1, JAK2 | JAK1 2/4885JAK3 1/4885JAK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.