Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.46 |
| ▸ | JAK1 | P23458 | 10/20 | 0.46 |
| ▸ | TYK2 | P29597 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | PRKCI | P41743 | 3/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1154015 | 0.86 | JAK2 (0.60) | JAK2JAK1TYK2JAK3ROCK1 | |
| SCHEMBL1154013 | 0.86 | JAK2 (0.60) | JAK2JAK1TYK2JAK3ROCK1 | |
| SCHEMBL12888143 | 0.86 | JAK2 (0.60) | JAK2JAK1TYK2JAK3ROCK1 | |
| SCHEMBL1154014 | 0.86 | JAK2 (0.60) | JAK2JAK1TYK2JAK3ROCK1 | |
| SCHEMBL24723930 | 0.76 | JAK2 (0.80) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL12876325 | 0.74 | JAK1 (0.62) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL12876038 | 0.72 | JAK2 (0.65) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL12876107 | 0.72 | JAK3 (0.60) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL12875971 | 0.71 | JAK2 (0.51) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL12876286 | 0.70 | JAK1 (0.57) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039822-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039822-A1 | HETEROCYCLIC JANUS KINASE 3 INHIBITORS | JAK3, JAK1, JAK2 | JAK2 3/4885JAK1 2/4885TYK2 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.