Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.79 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | STK17B | O94768 | 1/20 | 0.57 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.57 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12439852 | 0.89 | IGF1R (0.77) | IGF1R | |
| SCHEMBL11338910 | 0.88 | IGF1R (1.00) | IGF1RNTRK1 | |
| SCHEMBL15109533 | 0.88 | IGF1R (0.79) | IGF1RDAPK3STK17BDAPK1STK17A | |
| SCHEMBL12783949 | 0.87 | IGF1R (0.78) | IGF1RDAPK3STK17BDAPK1STK17A | |
| SCHEMBL4469873 | 0.84 | IGF1R (1.00) | IGF1R | |
| SCHEMBL12783997 | 0.83 | IGF1R (0.71) | IGF1RNTRK1 | |
| SCHEMBL2070672 | 0.81 | IGF1R (0.68) | IGF1RDAPK3NTRK1 | |
| SCHEMBL4745545 | 0.80 | IGF1R (0.59) | IGF1RDAPK3STK17BDAPK1STK17A | |
| SCHEMBL12784018 | 0.80 | IGF1R (0.81) | IGF1R | |
| SCHEMBL11343917 | 0.79 | IGF1R (1.00) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011019405-A1 | PYRIMIDINE COMPOUNDS AS TUBERCULOSIS INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-17 | — | — | WO | disclosed |