Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 10/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.58 |
| ▸ | ATM | Q13315 | 6/20 | 0.53 |
| ▸ | ATR | Q13535 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 3/20 | 0.48 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12764653 | 0.95 | MTOR (0.55) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL12764675 | 0.88 | MTOR (0.63) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL12761145 | 0.84 | PIK3CA (0.57) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL927530 | 0.84 | MTOR (0.56) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL928143 | 0.82 | MTOR (0.58) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL928008 | 0.82 | PIK3CD (0.62) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL930048 | 0.82 | MTOR (0.62) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL926905 | 0.82 | MTOR (0.62) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL12764674 | 0.81 | MTOR (0.59) | MTORPIK3CDPIK3CAPIK3CGPIK3CB | |
| SCHEMBL928379 | 0.81 | MTOR (0.61) | MTORPIK3CDPIK3CAPIK3CGPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270008-B1 | 8-heteroaryl-3-alkyl-1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as PI-3 kinases inhibitors | NOVARTIS AG (CH) | 2012-10-03 | — | — | EP | claimed |
| EP-2624831-A1 | PHARMACEUTICAL COMBINATIONS | Novartis AG (CH) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012047775-A1 | PHARMACEUTICAL COMBINATIONS | NOVARTIS AG (CH) | 2012-04-12 | — | — | WO | disclosed |
| EP-1888578-A2 | IMIDAZOQUINOLINES AS LIPID KINASE INHIBITORS | Novartis AG (CH) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006122806-A2 | 1,3-DIHYDRO-IMIDAZO [4,5-C] QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-11-23 | — | — | WO | disclosed |