Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 12/20 | 0.66 |
| ▸ | KDR | P35968 | 7/20 | 0.66 |
| ▸ | AURKA | O14965 | 4/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | FES | P07332 | 1/20 | 0.66 |
| ▸ | CSF1R | P07333 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | RET | P07949 | 1/20 | 0.66 |
| ▸ | IGF1R | P08069 | 1/20 | 0.66 |
| ▸ | MET | P08581 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | FGR | P09769 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | AKT1 | P31749 | 1/20 | 0.66 |
| ▸ | CSK | P41240 | 1/20 | 0.66 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264584 | 0.89 | TEK (0.83) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1264998 | 0.88 | TEK (0.84) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1264910 | 0.81 | TEK (0.84) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1264595 | 0.81 | TEK (0.85) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1266044 | 0.81 | TEK (0.80) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1264545 | 0.80 | TEK (0.82) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1263890 | 0.80 | TEK (0.81) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1264710 | 0.80 | TEK (0.90) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1265259 | 0.80 | TEK (1.00) | TEKKDRAURKALCKABL1 | |
| SCHEMBL1265824 | 0.80 | TEK (1.00) | TEKKDRAURKALCKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880000-B2 | N-(5-(1,1- dimethylethyl)-3- isoxazolyl)-4-methyl-3- ((3-(4-pyrimidinyl)-2- pyridinyl)amino)benzamide, used for treating breast cancer or rheumatoid arthritis | AMGEN INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-7880000-B2 | N-(5-(1,1- dimethylethyl)-3- isoxazolyl)-4-methyl-3- ((3-(4-pyrimidinyl)-2- pyridinyl)amino)benzamide, used for treating breast cancer or rheumatoid arthritis | AMGEN INC. (US) | 2011-02-01 | — | — | US | disclosed |