Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 14/20 | 0.81 |
| ▸ | KDR | P35968 | 12/20 | 0.81 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265603 | 0.90 | TEK (0.80) | TEKKDRYES1LCKMAPK14 | |
| SCHEMBL1264994 | 0.89 | TEK (1.00) | TEKKDRYES1LCKMAPK14 | |
| SCHEMBL2296918 | 0.89 | TEK (0.67) | TEKKDRLCKMAPK14JAK3 | |
| SCHEMBL1264439 | 0.83 | TEK (0.88) | TEKKDRYES1LCKMAPK14 | |
| SCHEMBL2297112 | 0.83 | TEK (1.00) | TEKKDR | |
| SCHEMBL1264167 | 0.83 | TEK (1.00) | TEKKDRYES1LCKMAPK14 | |
| SCHEMBL1264886 | 0.83 | KDR (0.70) | TEKKDRYES1LCKMAPK14 | |
| SCHEMBL1264864 | 0.81 | TEK (0.84) | TEKKDRYES1LCKMAPK14 | |
| SCHEMBL1265806 | 0.80 | TEK (0.78) | TEKKDR | |
| SCHEMBL1265761 | 0.78 | TEK (0.76) | TEKKDRYES1LCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880000-B2 | N-(5-(1,1- dimethylethyl)-3- isoxazolyl)-4-methyl-3- ((3-(4-pyrimidinyl)-2- pyridinyl)amino)benzamide, used for treating breast cancer or rheumatoid arthritis | AMGEN INC. (US) | 2011-02-01 | — | — | US | disclosed |
| US-7880000-B2 | N-(5-(1,1- dimethylethyl)-3- isoxazolyl)-4-methyl-3- ((3-(4-pyrimidinyl)-2- pyridinyl)amino)benzamide, used for treating breast cancer or rheumatoid arthritis | AMGEN INC. (US) | 2011-02-01 | — | — | US | disclosed |