Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 11/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.38 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | HIF1AN | Q9NWT6 | 2/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | VEGFA | P15692 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12896207 | 0.93 | EGLN1 (0.54) | EGLN1POLBFTOKDM6BHIF1AN | |
| SCHEMBL1270042 | 0.91 | EGLN1 (0.68) | EGLN1POLBFTOKDM6BHIF1AN | |
| SCHEMBL12896198 | 0.83 | EGLN1 (0.80) | EGLN1FTOALDH1A1BBOX1VEGFA | |
| SCHEMBL12896201 | 0.78 | EGLN1 (0.57) | EGLN1FTOLMNAALDH1A1MAPT | |
| SCHEMBL1269880 | 0.76 | EGLN1 (0.76) | EGLN1FTOBBOX1EGLN3THRA | |
| SCHEMBL12896206 | 0.76 | EGLN1 (0.56) | EGLN1FTOLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL12896210 | 0.75 | EGLN1 (0.77) | EGLN1FTOLMNAALDH1A1MAPT | |
| SCHEMBL1268889 | 0.75 | EGLN1 (0.67) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL1270012 | 0.75 | EGLN1 (0.73) | EGLN1FTOBBOX1EGLN3THRA | |
| SCHEMBL1270239 | 0.75 | EGLN1 (0.73) | EGLN1FTOKDM6BHIF1ANKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110028507-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | CRYSTALGENOMICS, INC. (KR) | 2011-02-03 | — | — | US | disclosed |
| US-20110028507-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | CRYSTALGENOMICS, INC. (KR) | 2011-02-03 | — | — | US | disclosed |
| WO-2009037570-A2 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | CRYSTALGENOMICS, INC. (KR) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028507-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | EGLN3, EGLN2, HIF1A | EGLN1 5/4885POLB 2092/4885FTO 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.