Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | PIKFYVE | Q9Y2I7 | 5/20 | 0.60 |
| ▸ | FES | P07332 | 1/20 | 0.60 |
| ▸ | FER | P16591 | 1/20 | 0.60 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
| ▸ | FRK | P42685 | 1/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL913093 | 1.00 | KDM4E (0.70) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL913095 | 1.00 | KDM4E (0.70) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL12903011 | 0.91 | KDM4E (0.68) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL913122 | 0.91 | KDM4E (0.68) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL913123 | 0.91 | KDM4E (0.68) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL913111 | 0.87 | KDM4E (0.72) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL12903005 | 0.87 | KDM4E (0.72) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL913109 | 0.87 | KDM4E (0.72) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL912360 | 0.85 | KDM4E (0.70) | KDM4EMAPTLMNAHPGDPIKFYVE | |
| SCHEMBL912362 | 0.85 | KDM4E (0.70) | KDM4EMAPTLMNAHPGDPIKFYVE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872005-B2 | 2-substituted heteroaryl compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-01-18 | — | — | US | disclosed |
| US-7872005-B2 | 2-substituted heteroaryl compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-01-18 | — | — | US | disclosed |