Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PIKFYVE | Q9Y2I7 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912259 | 1.00 | KMT2A (0.48) | KMT2AMAPTLMNAGAAMEN1 | |
| SCHEMBL913590 | 0.88 | MAPT (0.54) | KMT2AMAPTLMNAMEN1KDM4E | |
| SCHEMBL913589 | 0.88 | MAPT (0.54) | KMT2AMAPTLMNAMEN1KDM4E | |
| SCHEMBL913368 | 0.84 | PIKFYVE (0.48) | MAPTLMNAKDM4EHPGDPIKFYVE | |
| SCHEMBL12903014 | 0.84 | PIKFYVE (0.48) | KMT2AMAPTLMNAMEN1KDM4E | |
| SCHEMBL912824 | 0.81 | KDM4E (0.59) | KMT2AMAPTLMNAGAAHTT | |
| SCHEMBL912260 | 0.78 | POLB (0.41) | KMT2AMAPTLMNAMEN1HTT | |
| SCHEMBL912258 | 0.78 | POLB (0.41) | KMT2AMAPTLMNAMEN1HTT | |
| SCHEMBL913227 | 0.78 | KDM4E (0.57) | KMT2AMAPTLMNAGAAMEN1 | |
| SCHEMBL913226 | 0.78 | KDM4E (0.57) | KMT2AMAPTLMNAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872005-B2 | 2-substituted heteroaryl compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-01-18 | — | — | US | disclosed |
| US-7872005-B2 | 2-substituted heteroaryl compounds | SYNTA PHARMACEUTICALS CORPORATION (US) | 2011-01-18 | — | — | US | disclosed |