Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.33 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | MMP14 | P50281 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 6/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12864360 | 0.86 | DAO (0.45) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL12864345 | 0.86 | DAO (0.47) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL12903436 | 0.84 | DAO (0.43) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL12864358 | 0.81 | DAO (0.42) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL12903435 | 0.80 | DAO (0.41) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL12864353 | 0.80 | DAO (0.43) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL12864275 | 0.77 | DAO (0.55) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL12879946 | 0.76 | DAO (0.54) | DAOPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL1171008 | 0.75 | DAO (0.47) | DAOMMP2MMP13MMP14 | |
| SCHEMBL12863898 | 0.74 | DAO (0.51) | DAOPOLBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011017634-A2 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACORE INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2010017418-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-02-11 | — | — | WO | disclosed |