Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 9/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1171019 | 0.85 | DAO (0.51) | DAOKMT2AMMP2MMP13MMP14 | |
| SCHEMBL1171151 | 0.85 | DAO (0.57) | DAOKMT2ATDP1LMNAALDH1A1 | |
| SCHEMBL12864149 | 0.78 | DAO (0.48) | DAOKMT2ALMNAMAPK1ALDH1A1 | |
| SCHEMBL1171173 | 0.77 | DAO (0.63) | DAOKMT2ALMNAALDH1A1MMP2 | |
| SCHEMBL1171654 | 0.77 | DAO (0.63) | DAOKMT2ALMNAALDH1A1MMP2 | |
| SCHEMBL1171015 | 0.74 | DAO (0.59) | DAOKMT2ALMNAALDH1A1MMP2 | |
| SCHEMBL1171490 | 0.74 | DAO (0.59) | DAOKMT2ALMNAALDH1A1MMP2 | |
| SCHEMBL12904062 | 0.74 | DAO (0.59) | DAOKMT2ALMNAALDH1A1MMP2 | |
| SCHEMBL1170929 | 0.73 | DAO (0.58) | DAOKMT2ALMNAALDH1A1MMP2 | |
| SCHEMBL12864357 | 0.73 | DAO (0.48) | DAOKMT2ALMNAALDH1A1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011017634-A2 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACORE INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2010017418-A1 | PRODRUGS OF FUSED HETEROCYCLIC INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2010-02-11 | — | — | WO | disclosed |