Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.85 |
| ▸ | CTSD | P07339 | 6/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2607395 | 0.92 | BACE1 (1.00) | BACE1CTSDCYP3A4 | |
| SCHEMBL2607299 | 0.91 | BACE1 (0.98) | BACE1CTSDCYP3A4 | |
| SCHEMBL2609061 | 0.90 | BACE1 (0.85) | BACE1CTSDCYP3A4 | |
| SCHEMBL2607247 | 0.86 | BACE1 (0.86) | BACE1CTSD | |
| SCHEMBL12904399 | 0.85 | BACE1 (0.87) | BACE1CTSDCYP3A4 | |
| SCHEMBL12904404 | 0.85 | BACE1 (0.63) | BACE1CTSD | |
| SCHEMBL2607218 | 0.84 | BACE1 (0.85) | BACE1CTSDCYP3A4 | |
| SCHEMBL1762070 | 0.83 | BACE1 (0.73) | BACE1CTSDCYP3A4 | |
| SCHEMBL2607275 | 0.83 | BACE1 (0.84) | BACE1CTSDCYP3A4 | |
| SCHEMBL2607094 | 0.82 | BACE1 (0.82) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872009-B2 | Beta-Secretase modulators and methods of use | AMGEN INC. (US) | 2011-01-18 | — | — | US | disclosed |