Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Omeprazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A known ✓ | P20648 | 6/20 | 0.59 |
| ▸ | ATP4B known ✓ | P51164 | 6/20 | 0.59 |
| ▸ | BRS3 | P32247 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.59 |
| ▸ | ATP1A1 | P05023 | 5/20 | 0.59 |
| ▸ | ATP1B1 | P05026 | 5/20 | 0.59 |
| ▸ | ATP1A3 | P13637 | 5/20 | 0.59 |
| ▸ | ATP1B2 | P14415 | 5/20 | 0.59 |
| ▸ | ATP1A2 | P50993 | 5/20 | 0.59 |
| ▸ | ATP1B3 | P54709 | 5/20 | 0.59 |
| ▸ | FXYD2 | P54710 | 5/20 | 0.59 |
| ▸ | ATP1A4 | Q13733 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.59 |
| ▸ | WDR5 | P61964 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Omeprazole SCHEMBL2513318 | 1.00 | BRS3 (0.61) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL3699669 | 1.00 | BRS3 (0.61) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL2516731 | 1.00 | BRS3 (0.61) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL1293130 | 1.00 | BRS3 (0.61) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL1713670 | 0.99 | BRS3 (0.60) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL5803198 | 0.99 | BRS3 (0.60) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL1192 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL29360040 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Omeprazole SCHEMBL29772327 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 | |
| Esomeprazole SCHEMBL30426884 | 0.99 | BRS3 (0.62) | BRS3ATP4AATP4BCYP2C9ATP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102241668-B | Esomprazole salt | CHENGDU ORGANIC CHEMICALS CO., LTD., CHINESE ACADEMY OF SCIENCES (CN) | 2015-11-25 | — | — | CN | claimed |
| CN-102241668-A | New S-omeprazole salts | CHENGDU ORGANIC CHEMICALS CO | 2011-11-16 | — | — | CN | claimed |
| CN-101391993-A | Process for the preparation of S-omeprazole and its salts by forming an inclusion complex with (S)-(-)-1,1'-binaphthyl-2, 2'-diol | SHANGYU SHENGTAI BIOCHEMICAL C (CN) | 2009-03-25 | — | — | CN | claimed |
| WO-2007031845-A2 | POLYMORPHIC FORMS OF (S)-OMEPRAZOLE MAGNESIUM SALTS AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS LIMITED (US) | 2007-03-22 | — | — | WO | claimed |
| CN-1161351-C | Novel form of S-omeprazole | — | 2004-08-11 | — | — | CN | claimed |
| CN-1258295-A | Novel form of S-omeprazole | ASTRA AB (SE) | 2000-06-28 | — | — | CN | claimed |
| CN-102241668-B | Esomprazole salt | CHENGDU ORGANIC CHEMICALS CO., LTD., CHINESE ACADEMY OF SCIENCES (CN) | 2015-11-25 | — | — | CN | disclosed |
| CN-102131799-B | Method for splitting omeprazole salts | UNIV ROUEN | 2014-06-18 | — | — | CN | disclosed |
| US-8658799-B2 | Process for the preparation of crystalline modifications for use in the preparation of esomeperazole sodium salt | ASTRAZENECA AB (SE) | 2014-02-25 | — | — | US | disclosed |
| US-8592601-B2 | Precursor phase and use thereof for preparing the magnesium tetrahydrate salt of an omeprazole enantiomer | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2013-11-26 | — | — | US | disclosed |
| US-8466175-B2 | Form of S-omeprazole | ASTRAZENECA AB (SE) | 2013-06-18 | — | — | US | disclosed |
| US-8466175-B2 | Form of S-omeprazole | ASTRAZENECA AB (SE) | 2013-06-18 | — | — | US | disclosed |
| US-20120252847-A1 | NOVEL FORM OF S-OMEPRAZOLE | COTTON HANNA (SE) | 2012-10-04 | — | — | US | disclosed |
| CN-1258295-A | Novel form of S-omeprazole | ASTRA AB (SE) | 2000-06-28 | — | — | CN | disclosed |
| CN-1258295-A | Novel form of S-omeprazole | ASTRA AB (SE) | 2000-06-28 | — | — | CN | disclosed |
| EP-0984957-A1 | NOVEL FORM OF $i(S)OMEPRAZOLE | Astra Aktiebolag (SE) | 2000-03-15 | — | — | EP | disclosed |
| EP-0984957-A1 | NOVEL FORM OF $i(S)OMEPRAZOLE | Astra Aktiebolag (SE) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998054171-A8 | NOVEL FORM OF S-OMEPRAZOLE | ASTRA AB (SE) | 1999-12-23 | — | — | WO | disclosed |
| WO-1998054171-A1 | NOVEL FORM OF S-OMEPRAZOLE | ASTRA AKTIEBOLAG (SE) | 1998-12-03 | — | — | WO | disclosed |
| WO-1998054171-A1 | NOVEL FORM OF S-OMEPRAZOLE | ASTRA AKTIEBOLAG (SE) | 1998-12-03 | — | — | WO | disclosed |