SCHEMBL12933332

SCHEMBL12933332

CCCCn1cnc2c(NCC(C)(C)C)nc(Cl)nc21

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.59
HDAC2 Q92769 2/20 0.59
CTSL P07711 10/20 0.51
YTHDC1 Q96MU7 5/20 0.45
CDK1 P06493 2/20 0.44
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
NCOR2 Q9Y618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8348688 0.87 HDAC1 (0.64) HDAC1HDAC2CTSLYTHDC1CDK1
SCHEMBL12933325 0.86 HDAC1 (0.52) HDAC1HDAC2CTSLCDK1
SCHEMBL12963542 0.86 HDAC1 (0.69) HDAC1HDAC2CTSLYTHDC1HDAC3
SCHEMBL6817839 0.82 HDAC1 (0.67) HDAC1HDAC2CTSLYTHDC1HDAC3
SCHEMBL13906495 0.76 TLR9 (0.59) HDAC1HDAC2CTSL
SCHEMBL14024978 0.76 ADORA2A (0.62) HDAC1HDAC2CDK1
SCHEMBL28771447 0.74 PPARD (0.64) HDAC1CTSLYTHDC1
SCHEMBL5161283 0.74 HDAC1 (0.49) HDAC1HDAC2CTSLYTHDC1CDK1
SCHEMBL6821043 0.74 CDK2 (0.62) HDAC1HDAC2CTSLYTHDC1CDK1
SCHEMBL5161068 0.73 HDAC1 (0.51) HDAC1HDAC2CTSLYTHDC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7868204-B2 Inhibitors of histone deacetylase METHYLGENE INC. (CA) 2011-01-11 US disclosed
US-7838520-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2010-11-23 US disclosed
US-7595343-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2009-09-29 US disclosed
US-7595343-B2 Inhibitors of histone deacetylase METHYLGENE, INC. (CA) 2009-09-29 US disclosed