Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11939670 | 0.93 | POLB (0.48) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL12934944 | 0.91 | POLB (0.44) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL12935728 | 0.90 | CHRM1 (0.42) | POLBCHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL12935064 | 0.90 | KDM4E (0.47) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL11939236 | 0.90 | POLB (0.47) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL12935091 | 0.90 | POLB (0.46) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL12935111 | 0.89 | POLB (0.45) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL11940874 | 0.89 | KMT2A (0.49) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL11939772 | 0.88 | CHRM1 (0.46) | POLBCHRM1CHRM2CHRM4L3MBTL1 | |
| SCHEMBL12934699 | 0.88 | POLB (0.46) | POLBCHRM1CHRM2CHRM4L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863449-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863449-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-04 | — | — | US | disclosed |