Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12935235 | 0.97 | KDM4E (0.40) | KDM4EGPR119OPRM1OPRK1OPRL1 | |
| SCHEMBL12935400 | 0.92 | KDM4E (0.43) | KDM4EKCNH2MAPTCHRM1 | |
| SCHEMBL11940841 | 0.91 | KDM4E (0.41) | KDM4EOPRM1OPRK1OPRL1KCNH2 | |
| SCHEMBL12934842 | 0.89 | KDM4E (0.40) | KDM4EGPR119OPRL1ALDH1A1CHRM1 | |
| SCHEMBL11939234 | 0.89 | OPRL1 (0.41) | GPR119OPRM1OPRK1OPRL1KCNH2 | |
| SCHEMBL12935739 | 0.89 | KDM4E (0.40) | KDM4EOPRL1MAPTCHRM1 | |
| SCHEMBL12934774 | 0.88 | KDM4E (0.41) | KDM4EKCNH2MAPTCHRM1 | |
| SCHEMBL12935163 | 0.86 | KDM4E (0.39) | KDM4EOPRL1MAPTCHRM1 | |
| SCHEMBL12935092 | 0.86 | OPRL1 (0.39) | GPR119OPRM1OPRK1OPRL1KCNH2 | |
| SCHEMBL12934719 | 0.86 | KDM4E (0.38) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7863449-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-04 | — | — | US | disclosed |
| US-7863449-B2 | Modulators of muscarinic receptors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-01-04 | — | — | US | disclosed |