Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 6/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656474 | 0.94 | CCR1 (0.57) | CCR1CHRM2CCR5HTR1ASIGMAR1 | |
| SCHEMBL656475 | 0.94 | CCR1 (0.57) | CCR1CHRM2CCR5HTR1ASIGMAR1 | |
| SCHEMBL13617088 | 0.86 | CCR1 (0.48) | CCR1CHRM2CCR5HTR1ASIGMAR1 | |
| SCHEMBL651786 | 0.85 | CCR1 (0.60) | CCR1CHRM2CCR5HTR1ASIGMAR1 | |
| SCHEMBL651785 | 0.85 | CCR1 (0.60) | CCR1CHRM2CCR5HTR1ASIGMAR1 | |
| SCHEMBL12121948 | 0.84 | CCR1 (0.68) | CCR1CHRM2CCR5SIGMAR1KCNK2 | |
| SCHEMBL15478357 | 0.83 | CCR1 (0.63) | CCR1CHRM2CCR5SIGMAR1KCNK2 | |
| SCHEMBL16312649 | 0.82 | CCR1 (0.62) | CCR1CHRM2CCR5SIGMAR1KCNK2 | |
| SCHEMBL3836897 | 0.79 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D | |
| SCHEMBL3836896 | 0.79 | CCR1 (0.60) | CCR1CHRM2CCR5HRH1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2286811-A1 | Chemokine receptor antagonists and methods of use thereof | Millennium Pharmaceuticals, Inc. (US) | 2011-02-23 | — | — | EP | disclosed |