Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | PRKACG | P22612 | 1/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL942547 | 0.82 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL944398 | 0.80 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBPIK3CGGAK | |
| SCHEMBL13782176 | 0.80 | PIK3CA (0.82) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12943436 | 0.79 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGGAK | |
| SCHEMBL11938366 | 0.78 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBPIK3CGGAK | |
| SCHEMBL12961439 | 0.78 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGGAK | |
| SCHEMBL13781900 | 0.78 | PIK3CA (0.80) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL11938367 | 0.76 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CGGAK | |
| SCHEMBL13781913 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGGAK | |
| SCHEMBL13806165 | 0.74 | PIK3CA (0.79) | PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011000905-A1 | SUBSTITUTED 2-CARBOXAMIDE CYCLOAMINO UREAS | NOVARTIS AG (CH) | 2011-01-06 | — | — | WO | disclosed |