Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | PKM | P14618 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CBFB | Q13951 | 10/20 | 0.56 |
| ▸ | METAP2 | P50579 | 8/20 | 0.54 |
| ▸ | METAP1 | P53582 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.48 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124273 | 0.86 | CBFB (0.68) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL179152 | 0.82 | CBFB (0.58) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL125111 | 0.79 | CBFB (0.67) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL125289 | 0.78 | CBFB (0.65) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL13866537 | 0.76 | NPC1 (0.81) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL20350768 | 0.74 | CBFB (0.59) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL14906739 | 0.74 | CBFB (0.72) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL13223456 | 0.73 | NPC1 (1.00) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL124197 | 0.72 | CBFB (0.78) | NPC1RAB9APKMLMNASMN1; SMN2 | |
| SCHEMBL125153 | 0.71 | CBFB (1.00) | NPC1RAB9APKMLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132684-A9 | INHIBITORS OF INV(16) LEUKEMIA | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-01-06 | — | — | WO | disclosed |
| WO-2010132684-A2 | INHIBITORS OF INV(16) LEUKEMIA | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-11-18 | — | — | WO | disclosed |