Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BIRC3 | Q13489 | 14/20 | 0.60 |
| ▸ | XIAP | P98170 | 11/20 | 0.60 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.60 |
| ▸ | BIRC7 | Q96CA5 | 1/20 | 0.60 |
| ▸ | TNF | P01375 | 11/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL949556 | 1.00 | BIRC3 (0.60) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL25461010 | 1.00 | BIRC3 (0.60) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL12946306 | 1.00 | BIRC3 (0.60) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL14848210 | 1.00 | BIRC3 (0.60) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL12946533 | 0.97 | BIRC3 (0.57) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL22413625 | 0.97 | BIRC3 (0.57) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL10049925 | 0.96 | BIRC3 (0.58) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL19054947 | 0.96 | BIRC3 (0.58) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL19054996 | 0.93 | BIRC3 (0.53) | BIRC3XIAPBIRC2BIRC7TNF | |
| SCHEMBL30415980 | 0.89 | BIRC3 (0.49) | BIRC3XIAPBIRC2BIRC7TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230149500-A1 | SMAC MIMETIC | MEDIVIR AB (SE) | 2023-05-18 | — | — | US | disclosed |
| US-11351221-B2 | SMAC mimetic | MEDIVIR AB (SE) | 2022-06-07 | — | — | US | disclosed |
| US-20200282002-A1 | SMAC Mimetic | MEDIVIR AB (SE) | 2020-09-10 | — | — | US | disclosed |
| US-10596220-B2 | SMAC mimetic | MEDIVIR AB (SE) | 2020-03-24 | — | — | US | disclosed |
| US-20190255139-A1 | SMAC Mimetic | MEDIVIR AB (SE) | 2019-08-22 | — | — | US | disclosed |
| US-10314881-B2 | SMAC mimetic | MEDIVIR AB (SE) | 2019-06-11 | — | — | US | disclosed |
| US-10034912-B2 | SMAC Mimetic | TetraLogic Birinapant UK Ltd. (GB) | 2018-07-31 | — | — | US | disclosed |
| US-20170182116-A1 | SMAC Mimetic | MEDIVIR AB (SE) | 2017-06-29 | — | — | US | disclosed |
| EP-2448923-B1 | SMAC MIMETIC | TETRALOGIC PHARM CORP (US) | 2015-11-25 | — | — | EP | disclosed |
| US-20150158908-A1 | SMAC Mimetic for Treating Myelodysplastic Syndromes | TETRALOGIC BIRINAPANT UK LTD (GB) | 2015-06-11 | — | — | US | disclosed |
| US-8986993-B2 | SMAC mimetic for treating myelodysplastic syndromes | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2015-03-24 | — | — | US | disclosed |
| US-20140243276-A1 | SMAC MIMETIC (BIRINAPANT) FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES (CANCER) | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140073579-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2014-03-13 | — | — | US | disclosed |
| WO-2013049350-A1 | SMAC MIMETIC (BIRINAPANT) FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES (CANCER) | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2013-04-04 | — | — | WO | disclosed |
| US-20130012564-A1 | SMAC Mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2013-01-10 | — | — | US | disclosed |
| US-8283372-B2 | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2012-10-09 | — | — | US | disclosed |
| WO-2011002684-A1 | SMAC MIMETIC | TETRALOGIC PHARMACEUTICALS CORP. (US) | 2011-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012564-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20140243276-A1 | SMAC MIMETIC (BIRINAPANT) FOR USE IN THE TREATMENT OF PROLIFERATIVE DISEASES (CANCER) | BIRC5, BIRC3, BIRC7 | BIRC3 2/4885XIAP 10/4885BIRC2 4/4885 |
| US-10596220-B2 | SMAC mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20150158908-A1 | SMAC Mimetic for Treating Myelodysplastic Syndromes | MCL1, MPL, THPO | BIRC3 139/4885XIAP 82/4885BIRC2 132/4885 |
| US-10314881-B2 | SMAC mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20170182116-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-10034912-B2 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20230149500-A1 | SMAC MIMETIC | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-11351221-B2 | SMAC mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20140073579-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20200282002-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
| US-20190255139-A1 | SMAC Mimetic | SMARCC1, SMARCC2, MCL1 | BIRC3 14/4885XIAP 45/4885BIRC2 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.