Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
| ▸ | LNPEP | Q9UIQ6 | 13/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12945679 | 1.00 | NR1I2 (0.41) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12909708 | 0.89 | NR1I2 (0.56) | NR1I2CYP2E1LNPEP | |
| SCHEMBL936880 | 0.89 | NR1I2 (0.56) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12909797 | 0.89 | NR1I2 (0.56) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12945507 | 0.86 | NR1I2 (0.40) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12945346 | 0.86 | NR1I2 (0.40) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12945492 | 0.85 | NR1I2 (0.40) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12945814 | 0.84 | NR1I2 (0.39) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12945688 | 0.84 | NR1I2 (0.39) | NR1I2CYP2E1LNPEP | |
| SCHEMBL12945303 | 0.84 | NR1I2 (0.39) | NR1I2CYP2E1LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475657-B1 | 5-ALKINYLTHIEN-2-YLCARBOXYLIC ACIDS AS INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2013-06-12 | — | — | EP | disclosed |
| US-20110020278-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110020278-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | NR1I2 88/4885CYP2E1 6/4885LNPEP 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.