Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.57 |
| ▸ | PDE2A | O00408 | 19/20 | 0.57 |
| ▸ | PDE11A | Q9HCR9 | 5/20 | 0.57 |
| ▸ | PDE5A | O76074 | 4/20 | 0.57 |
| ▸ | PDE4A | P27815 | 3/20 | 0.57 |
| ▸ | PDE6D | O43924 | 2/20 | 0.43 |
| ▸ | PDE6A | P16499 | 2/20 | 0.43 |
| ▸ | PDE6G | P18545 | 2/20 | 0.43 |
| ▸ | PDE6B | P35913 | 2/20 | 0.43 |
| ▸ | PDE6C | P51160 | 2/20 | 0.43 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL970666 | 0.87 | PDE10A (0.55) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL12947964 | 0.87 | PDE2A (0.58) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL12948061 | 0.85 | PDE10A (0.60) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL969355 | 0.76 | PDE10A (0.67) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL970391 | 0.74 | PDE10A (0.77) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL969353 | 0.74 | PDE10A (0.52) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL972494 | 0.73 | PDE10A (0.72) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL971800 | 0.73 | PDE10A (1.00) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL972290 | 0.72 | PDE2A (1.00) | PDE10APDE2APDE11APDE5APDE4A | |
| SCHEMBL968670 | 0.72 | PDE10A (1.00) | PDE10APDE2APDE11APDE5APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875618-B2 | 8-chloro-3,4-dimethyl-1-(2- methylphenyl)imidazo[1,5- a]quinoxaline; inhibitors of phosphodiesterase 10; for treatment of central nervous system disorders (cognitive deficits, social phobia, reduced vigilance, obesity and psychosis) | WYETH (US) | 2011-01-25 | — | — | US | disclosed |