Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.61 |
| ▸ | GSK3B | P49841 | 8/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954514 | 0.90 | GSK3B (0.61) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL12952883 | 0.81 | CDK2 (0.76) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL12952919 | 0.79 | CDK2 (0.77) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL12953819 | 0.78 | GSK3B (0.61) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL12954113 | 0.78 | CDK2 (0.66) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL12953362 | 0.78 | CDK2 (0.68) | CDK2GSK3BCCNE1 | |
| SCHEMBL12954112 | 0.78 | CDK2 (0.70) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL13117942 | 0.77 | CDK2 (0.70) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL14582877 | 0.77 | CDK2 (0.72) | CDK2GSK3BCCNE1CCNA2CCNA1 | |
| SCHEMBL12953041 | 0.77 | CDK2 (0.69) | CDK2GSK3BCCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |