Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 15/20 | 0.37 |
| ▸ | CDK9 | P50750 | 15/20 | 0.37 |
| ▸ | CDK7 | P50613 | 4/20 | 0.35 |
| ▸ | CCNH | P51946 | 4/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCND1 | P24385 | 3/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK14 | O94921 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17690916 | 0.87 | PDE10A (0.49) | PDE10AKCNN3CCNT1CDK9CDK7 | |
| SCHEMBL12953173 | 0.81 | PDE10A (0.54) | PDE10AKCNN3CCNT1CDK9CDK7 | |
| SCHEMBL21877657 | 0.79 | PDE10A (0.56) | PDE10AKCNN3CCNT1CDK9CDK7 | |
| SCHEMBL12953397 | 0.77 | PDE10A (0.61) | PDE10ACCNT1CDK9CDK7CCNH | |
| SCHEMBL26871014 | 0.73 | PDE10A (0.51) | PDE10AKCNN3CCNT1CDK9CDK7 | |
| SCHEMBL26871265 | 0.72 | PDE10A (0.50) | PDE10AKCNN3CCNT1CDK9CDK7 | |
| SCHEMBL31465470 | 0.71 | PDE10A (0.61) | PDE10AKCNN3CCNT1CDK9CDK7 | |
| SCHEMBL14545874 | 0.71 | PDE10A (0.49) | PDE10ACCNT1CDK9CDK7CCNH | |
| SCHEMBL26870870 | 0.70 | PDE10A (0.51) | PDE10ACCNT1CDK9CDK7CCNH | |
| SCHEMBL12978823 | 0.69 | PDE10A (0.47) | PDE10AKCNN3CCNT1CDK9CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |