Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.55 |
| ▸ | C3AR1 | Q16581 | 5/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301720 | 0.91 | GSK3B (0.57) | GSK3BC3AR1CHEK1CCNE1CDK2 | |
| SCHEMBL13118987 | 0.91 | GSK3B (0.69) | GSK3BCCNE1CDK2 | |
| SCHEMBL14545821 | 0.89 | GSK3B (0.53) | GSK3BC3AR1CHEK1CHRM3CCNE1 | |
| SCHEMBL14613316 | 0.87 | GSK3B (0.55) | GSK3BCHEK1MAPK1HTTCCNE1 | |
| SCHEMBL13289192 | 0.86 | GSK3B (0.59) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13289048 | 0.85 | GSK3B (0.59) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13289043 | 0.85 | GSK3B (0.63) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL13288831 | 0.85 | GSK3B (0.59) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL12954326 | 0.85 | GSK3B (0.58) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14613296 | 0.84 | GSK3B (0.54) | GSK3BCHEK1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | SCHERING CORPORATION | 2007-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037824-A1 | Enzyme inhibitors from pyrazolo[1,5a]pyrimidine as enzyme inhibitors | CDK2, CDK5, CDKN1A | GSK3B 937/4885C3AR1 3939/4885CHEK1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.