Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.70 |
| ▸ | CDK2 | P24941 | 7/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305294 | 0.91 | GSK3B (0.71) | GSK3BCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL13116805 | 0.89 | GSK3B (0.70) | GSK3BCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL12953842 | 0.88 | GSK3B (0.54) | GSK3BCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL14418527 | 0.88 | GSK3B (0.57) | GSK3BCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL15579638 | 0.84 | GSK3B (0.52) | GSK3BCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL13304843 | 0.84 | GSK3B (0.53) | GSK3BCDK2CCNA2CCNA1CDK1 | |
| SCHEMBL12952848 | 0.83 | GSK3B (1.00) | GSK3BCDK2CCNE1 | |
| SCHEMBL14545204 | 0.82 | GSK3B (0.74) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953591 | 0.82 | GSK3B (0.98) | GSK3BCDK2CCNE1 | |
| SCHEMBL15579645 | 0.81 | GSK3B (0.47) | GSK3BCDK2CCNA2CCNA1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673924-B2 | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-03-18 | — | — | US | disclosed |
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |