Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.50 |
| ▸ | CDK9 | P50750 | 9/20 | 0.50 |
| ▸ | CDK1 | P06493 | 8/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.50 |
| ▸ | CDK7 | P50613 | 11/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.46 |
| ▸ | CCNH | P51946 | 6/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | CDK4 | P11802 | 4/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.45 |
| ▸ | CDK8 | P49336 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | CCND1 | P24385 | 2/20 | 0.45 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953698 | 0.85 | CDK2 (0.69) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL12953697 | 0.85 | CDK2 (0.47) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL12954261 | 0.84 | CDK2 (0.46) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL12952983 | 0.84 | CDK2 (0.47) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL12953723 | 0.84 | CDK2 (0.55) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL12953797 | 0.83 | CDK2 (0.49) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL11930883 | 0.82 | CDK2 (0.43) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL14043244 | 0.78 | CDK2 (0.40) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL14545811 | 0.78 | GSK3B (0.52) | CDK2CDK9CDK1CDK5CDK7 | |
| SCHEMBL12954128 | 0.76 | GSK3B (0.51) | CDK2CDK7CCNE1CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |