Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288981 | 0.93 | CDK2 (0.46) | CDK2GSK3BCCR1KDM4EMAPT | |
| SCHEMBL13289301 | 0.91 | CDK2 (0.46) | CDK2GSK3BMEN1KMT2ACCR1 | |
| SCHEMBL13121099 | 0.90 | CDK2 (0.56) | CDK2GSK3BGAAMEN1KMT2A | |
| SCHEMBL13289474 | 0.90 | GSK3B (0.46) | CDK2GSK3BGAAMEN1KMT2A | |
| SCHEMBL13289466 | 0.88 | GSK3B (0.43) | CDK2GSK3BMEN1KMT2ACCR1 | |
| SCHEMBL13289251 | 0.88 | CDK2 (0.45) | CDK2GSK3BCCR1 | |
| SCHEMBL12954453 | 0.88 | CDK2 (0.44) | CDK2GSK3BMEN1KMT2APOLB | |
| SCHEMBL13289243 | 0.88 | GSK3B (0.46) | CDK2GSK3BGAAMEN1KMT2A | |
| SCHEMBL13289089 | 0.88 | CDK2 (0.44) | CDK2GSK3BMEN1KMT2ACCR1 | |
| SCHEMBL13289128 | 0.88 | CDK2 (0.44) | CDK2GSK3BPOLBCCR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |