Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289814 | 0.92 | GSK3B (0.57) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL13122143 | 0.91 | GSK3B (0.68) | GSK3BCDK2CCNE1 | |
| SCHEMBL14301734 | 0.91 | GSK3B (0.58) | GSK3BCHEK1ROCK2PDE2ACDK2 | |
| SCHEMBL14418660 | 0.90 | GSK3B (0.57) | GSK3BCHEK1PDE2ACDK2CCNE1 | |
| SCHEMBL14301721 | 0.89 | GSK3B (0.55) | GSK3BCHEK1ROCK2PDE2ACDK2 | |
| SCHEMBL14613421 | 0.89 | GSK3B (0.55) | GSK3BCHEK1ROCK2PDE2ACDK2 | |
| SCHEMBL14301605 | 0.88 | GSK3B (0.53) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL14545902 | 0.88 | GSK3B (0.56) | GSK3BCHEK1PDE2ACDK2CCNE1 | |
| SCHEMBL14613420 | 0.87 | GSK3B (0.54) | GSK3BCHEK1ROCK2CDK2CCNE1 | |
| SCHEMBL14613386 | 0.87 | GSK3B (0.57) | GSK3BCHEK1PDE2ACDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |