Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.51 |
| ▸ | GSK3B | P49841 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289523 | 0.97 | CDK2 (0.52) | CDK2GSK3BKDM4EMAPTMAPK1 | |
| SCHEMBL13305342 | 0.93 | CDK2 (0.53) | CDK2GSK3BKDM4EMAPTMAPK1 | |
| SCHEMBL13305234 | 0.90 | CDK2 (0.51) | CDK2GSK3BKDM4EMAPTMAPK1 | |
| SCHEMBL13289308 | 0.89 | CDK2 (0.53) | CDK2GSK3BKDM4EMAPTMAPK1 | |
| SCHEMBL13304992 | 0.88 | CDK2 (0.52) | CDK2GSK3BKDM4EMAPTMAPK1 | |
| SCHEMBL13118418 | 0.88 | CDK2 (0.67) | CDK2GSK3B | |
| SCHEMBL13289793 | 0.87 | CDK2 (0.52) | CDK2GSK3BMAPTNPC1RAB9A | |
| SCHEMBL13289182 | 0.86 | CDK2 (0.46) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL13289896 | 0.86 | GSK3B (0.48) | CDK2GSK3BKDM4EMAPTMAPK1 | |
| SCHEMBL12953652 | 0.86 | GSK3B (0.55) | CDK2GSK3BMEN1KMT2AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |