Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.79 |
| ▸ | CDK2 | P24941 | 14/20 | 0.70 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.65 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954188 | 0.91 | GSK3B (0.79) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL14050928 | 0.89 | GSK3B (0.61) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13118479 | 0.88 | GSK3B (1.00) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953672 | 0.87 | GSK3B (0.72) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953936 | 0.84 | GSK3B (0.77) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953490 | 0.83 | GSK3B (0.81) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953516 | 0.83 | GSK3B (0.66) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953328 | 0.83 | CDK2 (1.00) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12952856 | 0.82 | CDK2 (1.00) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL14043202 | 0.82 | GSK3B (0.72) | GSK3BCDK2CCNA2CCNA1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |