Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289844 | 0.91 | GSK3B (0.56) | GSK3BCHEK1TRPV6CDK2CCNE1 | |
| SCHEMBL13122087 | 0.91 | GSK3B (0.71) | GSK3BCDK2CCNE1 | |
| SCHEMBL14418875 | 0.85 | GSK3B (0.56) | GSK3BCHEK1TRPV6CDK2CCNE1 | |
| SCHEMBL13122079 | 0.85 | GSK3B (0.70) | GSK3BTRPV6CDK2CCNE1 | |
| SCHEMBL13122032 | 0.83 | GSK3B (0.72) | GSK3BCDK2CCNE1 | |
| SCHEMBL13289453 | 0.83 | GSK3B (0.57) | GSK3BCHEK1CDK2 | |
| SCHEMBL13122200 | 0.82 | GSK3B (0.67) | GSK3BCDK2CCNE1 | |
| SCHEMBL14613420 | 0.82 | GSK3B (0.54) | GSK3BCHEK1TRPV6CDK2CCNE1 | |
| SCHEMBL14043403 | 0.82 | GSK3B (0.60) | GSK3BCHEK1CDK2CCNE1 | |
| SCHEMBL14546041 | 0.82 | GSK3B (0.53) | GSK3BCHEK1CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |